Self-declared stock ownership and association with positive trial outcome in randomized controlled studies with binary results posted in general medical journals a cross-sectional research

Self-declared stock ownership and association with positive trial outcome in randomized controlled studies with binary results posted in general medical journals a cross-sectional research

Trials amount 18, Article number 354 ( 2017 ) Cite this article

Abstract

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Background

Describe the prevalence and kinds of conflicts of great interest (COI) in published randomized managed trials (RCTs) generally speaking medical journals by having a binary primary result and measure the association between conflicts of great interest and favorable outcome.

Methods

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Parallel-group RCTs by having a binary outcome that is primary in three basic medical journals during 2013–2015 were identified. COI type, funding source, and result had been removed. Binomial regression that is logistic ended up being performed to evaluate association between COI and funding source with outcome.

Outcomes

A complete of 509 consecutive parallel-group RCTs were included in the study. COI was reported in 74% in mixed funded RCTs as well as in 99% in for-profit RCTs that is funded. Stock ownership had been reported in none of this non-profit RCTs, in 7% of mixed funded RCTs, and in 50% of for-profit funded RCTs. Mixed-funded RCTs had employees through the capital company in 11% and RCTs that is for-profit 76%. Multivariable logistic regression revealed that stock ownership in the money business among some of the authors was connected with a favorable result (odds ratio = 3.53; 95% self- confidence interval = 1.59–7.86; p

Background

Randomized controlled trials (RCTs) financed by industry (for-profit) are related to more favorable outcomes compared with other forms of capital sources [1], partly explained by the use of surrogate endpoints ( e.g. (more…)

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